I can't think of anything so Skullgirls.

An anime nurse saying "i don't know that game"

a nurse in training avoids his upcoming brain surgery by asking the doctors "Can't we play monopoly?"

Real-Life Operation - "Don't touch the sides!*" *Until you've signed the included waver.

kirby with yellow eyes a monobrow and a blue heart for a mouth

Kirby with yellow eyes, brown eyebrows, and a blue mouth.