Twilight freaks out that Celestia turned human and passed out, while Chrysalis eats a wedge of cheese.

Twilight has destroyed the fabric of space and time. Again.

Pony with cancer

Impostor Rainbow Dash

... what? That's not a pony.

A pony making an excuse for being overweight.

A blonde human doing a bad Big Macintosh impression.

Applejack and Tank fuse together

Rarity as a fluffy dog.

Twilight looking at a picture of a sad Pikachu